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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAN All Species: 33.33
Human Site: S347 Identified Species: 52.38
UniProt: Q9NQ55 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ55 NP_001035754.1 473 53194 S347 R E A H R K K S L E G M K K A
Chimpanzee Pan troglodytes XP_001150990 706 78742 S347 R E A H R K K S L E G M K K A
Rhesus Macaque Macaca mulatta XP_001100297 471 52923 S347 R E A H R K K S L Q G M K K A
Dog Lupus familis XP_533920 792 88144 S347 R E A H K K K S L A G M K R T
Cat Felis silvestris
Mouse Mus musculus Q91YU8 470 52707 S347 R E A H K K K S L A G I K R A
Rat Rattus norvegicus NP_001011980 470 52521 S347 R E A H K K K S L A G I K R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519003 490 55177 S347 R E A H K K R S L A G M K R K
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_958871 522 59529 S346 R D L N K K R S L E G I K R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VDE5 460 53074 A328 E Q R K K E Q A E N R A R N L
Honey Bee Apis mellifera XP_395421 413 48031 G306 A I R L S E L G P R L T L E L
Nematode Worm Caenorhab. elegans NP_491108 573 63766 R358 K K Q M K K R R E Q E S E Q R
Sea Urchin Strong. purpuratus XP_787585 300 34175 S196 R I E F R H Y S I K A V P M G
Poplar Tree Populus trichocarpa XP_002302711 297 33281 I193 I D F R H Y S I K L Q P V G V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ASU7 345 38823 G241 S D F V T K A G Y G S E S E G
Baker's Yeast Sacchar. cerevisiae P38789 453 51746 T336 T E L G P R L T L K L V K I E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.1 95.7 48.8 N.A. 73.3 73.5 N.A. 62 N.A. N.A. 53 N.A. 35 38.9 31.4 36.3
Protein Similarity: 100 65.4 97.4 54 N.A. 81.6 81.8 N.A. 75.3 N.A. N.A. 70.1 N.A. 57.5 59.2 49.5 47.9
P-Site Identity: 100 100 93.3 73.3 N.A. 73.3 73.3 N.A. 66.6 N.A. N.A. 46.6 N.A. 0 0 6.6 20
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 86.6 N.A. N.A. 86.6 N.A. 40 13.3 53.3 40
Percent
Protein Identity: 28.7 N.A. N.A. 32.9 25.5 N.A.
Protein Similarity: 42.9 N.A. N.A. 50.5 44.8 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 20 N.A.
P-Site Similarity: 6.6 N.A. N.A. 20 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 47 0 0 0 7 7 0 27 7 7 0 0 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 20 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 54 7 0 0 14 0 0 14 20 7 7 7 14 7 % E
% Phe: 0 0 14 7 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 14 0 7 54 0 0 7 14 % G
% His: 0 0 0 47 7 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 14 0 0 0 0 0 7 7 0 0 20 0 7 0 % I
% Lys: 7 7 0 7 47 67 40 0 7 14 0 0 60 20 14 % K
% Leu: 0 0 14 7 0 0 14 0 60 7 14 0 7 0 14 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 34 0 7 0 % M
% Asn: 0 0 0 7 0 0 0 0 0 7 0 0 0 7 0 % N
% Pro: 0 0 0 0 7 0 0 0 7 0 0 7 7 0 0 % P
% Gln: 0 7 7 0 0 0 7 0 0 14 7 0 0 7 0 % Q
% Arg: 60 0 14 7 27 7 20 7 0 7 7 0 7 34 7 % R
% Ser: 7 0 0 0 7 0 7 60 0 0 7 7 7 0 0 % S
% Thr: 7 0 0 0 7 0 0 7 0 0 0 7 0 0 7 % T
% Val: 0 0 0 7 0 0 0 0 0 0 0 14 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 7 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _